Crucial Role in Reproduction: Estradiol is essential for the development and maintenance of female reproductive tissues, including the uterus and breasts.
Menstrual Cycle Regulation: It plays a key role in regulating the menstrual cycle, contributing to hormonal balance and fertility.
Secondary Sexual Characteristics: Estradiol is vital for the development of secondary sexual characteristics in females, such as breast development.
Physiological Influence: Estradiol impacts various bodily functions, from bone health to cardiovascular function, highlighting its wide physiological significance.
Estradiol is a steroid hormone primarily produced by the ovarian follicles, corpus luteum, and placenta during pregnancy. It is considered the most significant and biologically active form of estrogen in the body. Estradiol plays a crucial role in the development and maintenance of female reproductive tissues, including the uterus and breasts.
It also contributes to the regulation of the menstrual cycle and is vital for the development of secondary sexual characteristics in females. Due to its powerful effects on cellular processes, estradiol influences a wide range of physiological functions, from bone health to cardiovascular function.
Parameters
| Melting point | 178-179 °C(lit.) |
| alpha | D25 +76 to +83° (dioxane) |
| Boiling point | 355.44°C (rough estimate) |
| density | 1.0708 (rough estimate) |
| refractive index | 80.4 ° (C=1, Dioxane) |
| Fp | 2℃ |
| storage temp. | room temp |
| solubility | Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride. |
| pka | pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate) |
| form | powder |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils. |
| Merck | 143703 |
| BRN | 1914275 |
| BCS Class | 1 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | VOXZDWNPVJITMN-ZBRFXRBCSA-N |
| CAS DataBase Reference | 50-28-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2) |
| EPA Substance Registry System | Estradiol (50-28-2) |
| Safety Information | |
| Hazard Codes | T,Xn,F |
| Risk Statements | 60-61-45-63-64-40-36-20/21/22-11-48 |
| Safety Statements | 53-22-36/37/39-45-36/37-26-16-36-20 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | KG2975000 |
| F | 45879 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29372390 |
| Hazardous Substances Data | 50-28-2(Hazardous Substances Data) |
| Toxicity | LD50 subcutaneous in rat: > 300mg/kg |
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