Superior Catalytic Efficiency – Acts as a highly effective phase transfer catalyst to accelerate reactions.
Chromatography Application – Widely used as a buffer salt system in reversed-phase liquid chromatography.
Enhanced Analytical Precision – Helps improve separation performance and detection accuracy.
Versatile Utility – Applicable in both chemical synthesis and analytical testing fields.
Tetrabutyl quaternary ammonium salts serve as highly efficient phase transfer catalysts. The tetrabutylammonium hydrogen sulfate buffer system is commonly applied as an aqueous mobile phase in reversed-phase liquid chromatography. However, as the concentration of tetrabutylammonium hydrogen sulfate increases, the stability of this buffer system gradually decreases. Therefore, the buffer solution should be freshly prepared prior to use, and its effective usage time should not exceed 6 hours. After about 8 hours at room temperature, noticeable turbidity may occur, which can lead to chromatographic peak drift and even salt precipitation within the pump or chromatographic column, potentially causing serious damage to the equipment.
Tetrabutylammonium hydrogen sulfate Chemical Properties
| Melting point | 171-174 °C |
| Boiling point | 213.3-593.92℃[at 101 325 Pa] |
| Density | 1.01 |
| Vapor pressure | 0Pa at 25℃ |
| Storage temp | Store below +30°C. |
| Solubility | H2O: soluble10% (w/v), clear, colorless |
| Form | Solution |
| Specific Gravity | 1.01 |
| Color | White to beige |
| PH | 1-2 (100g/l, H2O, 20℃) |
| Odor | Amine like |
| PH Range | 1 – 2 |
| Water Solubility | Soluble |
| Sensitive | Hygroscopic |
| λmax | λ: 210 nm Amax: 0.06 λ: 220 nm Amax: 0.05 λ: 230 nm Amax: 0.03 λ: 260 nm Amax: 0.02 λ: 500 nm Amax: 0.02 |
| BRN | 3599663 |
| Stability | Stable, but moisture sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | SHFJWMWCIHQNCP-UHFFFAOYSA-M |
| LogP | 0.96 at 25℃ |
| CAS DataBase Reference | 32503-27-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Tetrabutylammonium hydrogen sulfate(32503-27-8) |
| EPA Substance Registry System | Tetrabutylammonium sulfate (1:1) (32503-27-8) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| F | 8-10 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29239000 |
Tetrabutylammonium hydrogen sulfate can function as a surfactant, catalyst, emulsifier, disinfectant, bactericide, and antistatic agent. In addition, its buffer system is widely employed as an aqueous mobile phase in reversed-phase liquid chromatography, often delivering outstanding separation results for certain structurally unique compounds that are otherwise difficult to separate.
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