1. Pain Relief and Anti-Inflammatory: Aspirin is a proven NSAID, widely used for its anti-inflammatory and pain-relieving properties.
2. Antithrombotic Effects: It inhibits platelet aggregation, providing antithrombotic effects, making it effective in preventing blood clots.
3. Cardiovascular Benefits: Aspirin lowers the risk of fatal myocardial infarction and stroke, improving heart health.
4. Cancer Prevention: Research shows that aspirin may reduce the likelihood of developing colorectal cancer, enhancing its therapeutic value.
Aspirin, chemically referred to as acetylsalicylic acid, is a nonsteroidal anti-inflammatory drug (NSAID) initially employed for its anti-inflammatory and pain-relieving properties. Subsequently, researchers found that aspirin inhibits platelet clumping, thereby producing antithrombotic effects. As scientific investigations into aspirin have progressed, numerous additional applications have been identified. For instance, aspirin has been shown to lower the fatality rate associated with myocardial infarction and stroke, as well as decrease the likelihood of developing colorectal cancer.
| Melting point | 134-136 °C (lit.) |
| Boiling point | 272.96°C (rough estimate) |
| density | 1.35 |
| refractive index | 1.4500 (estimate) |
| Fp | 250 °C |
| storage temp. | 2-8°C |
| solubility | H2O: 10 mg/mL at 37 °C |
| form | crystalline |
| color | white |
| pka | 3.5(at 25℃) |
| biological source | synthetic |
| Water Solubility | 3.3 g/L (20 ºC) |
| ε(extinction coefficient) | 190 at 298nm in aqueous base at 1mM |
| 409 at 231nm in aqueous base at 1mM | |
| 466 at 230nm in aqueous acid at 1mM | |
| 68 at 278nm in aqueous acid at 1mM | |
| Merck | 14851 |
| BRN | 779271 |
| Exposure limits | ACGIH: TWA 5 mg/m3 |
| NIOSH: TWA 5 mg/m3 | |
| BCS Class | 3 |
| Stability: | Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc. |
| InChIKey | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
| LogP | 1.19 |
| CAS DataBase Reference | 50-78-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 2-(acetyloxy)-(50-78-2) |
| EPA Substance Registry System | Aspirin (50-78-2) |
| Safety Information | |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37/39 |
| OEB | B |
| OEL | TWA: 5 mg/m3 |
| RIDADR | UN 1851 |
| WGK Germany | 1 |
| RTECS | VO0700000 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29182210 |
| Hazardous Substances Data | 50-78-2(Hazardous Substances Data) |
| Toxicity | LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart) |
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