1. Water Solubility: Easily dissolves in water, making it highly versatile for various applications, including pharmaceuticals and food products.
2. Temperature-Responsive: Exhibits a reversible sol-to-gel transition with heating and cooling, suitable for applications requiring this unique behavior.
3. Surface-Active Properties: Forms a film upon drying, which is beneficial for use in coatings, adhesives, and controlled release systems.
4. Stable and Safe: Stable under normal conditions, with low toxicity and compatibility with a wide range of formulations.
Hydroxypropyl methyl cellulose (HPMC) is a derivative of methyl cellulose, where hydroxypropyl and methyl groups are attached to the anhydrous glucose ring through ether bonds. It appears as a white or off-white powder or granules. Various forms of HPMC exist, each differing in the ratio of methoxy to hydroxypropyl content. The product typically appears as white or gray fibrous powder or particles.
HPMC is soluble in water and some organic solvents but is insoluble in ethanol. When dissolved in water, it exhibits surface-active properties and forms a film upon drying. Additionally, it undergoes a reversible transformation from sol to gel when subjected to heating and cooling. This unique characteristic makes it suitable for applications that require temperature-responsive behavior.
| Hydroxypropyl methyl cellulose Chemical Properties |
| Melting point | 225-230 °C |
| density | 1.39 |
| storage temp. | room temp |
| solubility | H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow |
| form | powder |
| color | White to cream |
| Odor | Odorless |
| PH | 5.0-8.0 |
| biological source | plant |
| Water Solubility | SOLUBLE |
| Merck | 14,4842 |
| Stability: | Stable. Solid is combustible, incompatible with strong oxidizing agents. |
| EPA Substance Registry System | 2-Hydroxypropyl methyl cellulose (9004-65-3) |
| Safety Information |
| Safety Statements | 24/25 |
| WGK Germany | 1 |
| RTECS | NF9125000 |
| F | 3-10 |
| TSCA | Yes |
| HS Code | 39129000 |
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