1. Effective Pain and Inflammation Relief: Ibuprofen is a widely used NSAID known for its strong anti-inflammatory, pain-relieving, and fever-reducing effects.
2. Minimal Side Effects: It offers an effective solution for pain management with fewer side effects compared to other NSAIDs, making it a popular choice.
3. Versatile Use: Ibuprofen is globally accepted as a go-to over-the-counter medication for conditions like arthritis, muscle pain, and headaches.
4. Stable and Safe Storage: It remains stable and safe for use when stored in a cool, dry environment, offering reliability in both storage and effectiveness.
Ibuprofen, chemically named isobutylphenyl propionic acid, belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). This medication demonstrates effective anti-inflammatory, pain-relieving, and fever-reducing properties while exhibiting minimal side effects. Its global acceptance has made it one of the most widely sold over-the-counter medications worldwide. Alongside aspirin and paracetamol, ibuprofen is recognized as one of the three fundamental antipyretic and analgesic products.
In China, this drug is primarily utilized for pain management and rheumatism treatment, with comparatively limited application for treating colds and reducing fever – a usage pattern that significantly trails behind that of paracetamol and aspirin.
| Melting point | 77-78 °C |
| Boiling point | 157 °C (4 mmHg) |
| alpha | [α]D20 -1～+1°(c=1,C2H5OH) |
| density | 1.0364 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in acetone, in methanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides and carbonates. |
| pka | pKa 4.45± 0.04(H2O,t = 25±0.5,I=0.15(KCl))(Approximate) |
| form | Crystalline Powder |
| color | white to off-white |
| biological source | synthetic (organic) |
| Water Solubility | insoluble |
| Merck | 144881 |
| BCS Class | 2 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | HEFNNWSXXWATRW-UHFFFAOYSA-N |
| LogP | 3.97 |
| CAS DataBase Reference | 15687-27-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Ibuprofen(15687-27-1) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)- (15687-27-1) |
| Safety Information | |
| Hazard Codes | Xn |
| Risk Statements | 22-63-51/53-39/23/24/25-23/24/25-11 |
| Safety Statements | 36-61-36/37-45-16-7 |
| HS Code | 29163920 |
| Hazardous Substances Data | 15687-27-1(Hazardous Substances Data) |
| Toxicity | LD50 in male mice, rats (mg/kg): 495, 626 i.p.; 1255, 1050 orally (Orzalesi) |
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