Enhances Drug Solubility: Meglumine is widely used as a counter ion to significantly improve the solubility of poorly soluble drugs.
Improves Bioavailability: By increasing drug solubility, meglumine helps enhance the bioavailability and therapeutic effectiveness of active pharmaceutical ingredients.
Well-Established Pharmaceutical Counter Ion: It is a commonly used and well-recognized counter ion in pharmaceutical formulations, offering reliable and proven performance.
Favorable Chemical Properties: As an amino sugar derived from sorbitol with a pKa of about 9.6, meglumine provides suitable ionization characteristics for forming stable drug salts.
Products Description of Meglumine CAS#6284-40-8
Selecting an appropriate counter-ion is crucial for enhancing the solubility and bioavailability of pharmaceutical compounds. Meglumine (N-methyl-D-glucosamine) is a commonly used counter-ion that effectively improves drug solubility. It is an amino sugar derived from sorbitol and has a pKa of approximately 9.6.
Meglumine Chemical Properties
| Melting point | 129-131.5 °C (lit.) |
| Alpha | -16.5 º (c=10, H2O, on dry sub) |
| Boiling point | 331.88°C (rough estimate) |
| Density | 1.2669 (rough estimate) |
| Refractive index | -16.5 ° (C=2, H2O) |
| RTECS | LZ4295770 |
| Storage temp | 2-8°C |
| Solubility | H2O: 0.1 g/mL, clear, colorless |
| Form | Crystalline Powder |
| Pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| Color | White to almost white |
| PH | 11 (10g/l, H2O, 20℃) |
| Optical activity | [α]20/D 16.5±0.5°, c = 2% in H2O |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 146,078 |
| BRN | 385906 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
| LogP | -3.370 (est) |
| NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
| EPA Substance Registry System | Meglumine (6284-40-8) |
Safety Information
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| F | 2003/10/23 |
| Autoignition Temperature | ~662 °F |
| TSCA | Yes |
| HS Code | 29221980 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
Product Application of Meglumine CAS#6284-40-8
Cosolvents and surfactants used as contrast agents; their applications in diagnostic drugs; cosolvents and surfactants for contrast agents.
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