1. Effective Antibiotic: Streptomycin sulfate is highly effective in treating tuberculosis, especially extracellular bacteria.
2. Bactericidal Action: It targets bacterial ribosomes to inhibit protein synthesis, providing a powerful treatment option.
3. Low Toxicity: One of the least toxic antibiotics derived from Streptomyces, making it safer for medical use.
4. Stable Formulation: It is stable under proper storage conditions, with a shelf-life that supports its medical efficacy.
Streptomycin sulfate is the sulfate salt form of streptomycin, an antibiotic derived from the soil bacterium Streptomyces griseus. Streptomycin was the first chemotherapy drug developed that has a proven effect on tuberculosis, making it a significant medical advancement. This product requires intramuscular injection for administration, limiting its long-term usage.
As one of the most effective and least toxic antibiotics derived from Streptomyces, it is primarily used for extra-gastrointestinal treatments. Streptomycin sulfate acts as a bactericidal agent, working by directly targeting bacterial ribosomes and inhibiting protein synthesis. Its primary application is in the treatment of extracellular tuberculosis bacteria, including those present in cavities.
Parameters
| Melting point | >185°C (dec.) |
| alpha | -79～-88°(20℃/D)(c=1,H2O)(calculated on the dried basis) |
| density | 1.2302 (rough estimate) |
| refractive index | -85 ° (C=1, H2O) |
| storage temp. | 2-8°C |
| solubility | H2O: 0.1 g/mL, clear |
| form | powder |
| color | white to off-white |
| PH | pH (100g/l, 25℃) : 4.5～7.0 |
| Water Solubility | >=0.01 g/100 mL at 18 ºC |
| Merck | 148826 |
| BRN | 3894995 |
| Specific Activity | ≥720IU/g (dry basis) |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | QTENRWWVYAAPBI-YZTFXSNBSA-N |
| LogP | -1.523 (est) |
| CAS DataBase Reference | 3810-74-0 |
| EPA Substance Registry System | Streptomycin sulfate (3810-74-0) |
| Safety Information | |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-63-42/43 |
| Safety Statements | 26-36-36/37-45-22-60 |
| WGK Germany | 3 |
| RTECS | WK4990000 |
| F | 3 |
| TSCA | Yes |
| HS Code | 29412000 |
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